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Manufacture of a pharmaceutical composition containing a myxoma virus, pharmaceutical composition comprising a myxoma virus and ex-vivo use of same
Manufacture of a pharmaceutical composition containing a myxoma virus, pharmaceutical composition comprising a myxoma virus and ex-vivo use of same
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机译:含有粘液瘤病毒的药物组合物的制造,包含粘液瘤病毒的药物组合物及其离体用途
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摘要
The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.
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