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Method of determining risk of alzheimer's disease based on the presence or absence of variants in the tomm40 gene
Method of determining risk of alzheimer's disease based on the presence or absence of variants in the tomm40 gene
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机译:根据tomm40基因中是否存在变体来确定阿尔茨海默氏病风险的方法
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摘要
Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided..
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