SYSTEMS AND METHODS FOR SCALE UP OF CONTINUOUS FLOW REACTORS

摘要

A method is disclosed for the seamless scale up of a micro reactor process to transfer lab test to a pilot or production unit the process comprising the steps of using a wall material for the lab reactor with a thermal conductivity lower than 3 W/m K and using a wall material for the production reactor with a thermal conductivity higher than 5 W/m K. According to one preferred embodiment the velocity is kept constant and the height of the channel is determined in order to keep the volumetric heat transfer properties constant according to the formula: wherein H is the overall volumetric heat transfer coefficient in the pilot or production process; A B and C are constants; D is the hydraulic diameter of the channel in the pilot or production process; ? is the thermal conductivity of the wall in the pilot or production process; b is the empirically determined power to which the Reynolds number is raised in the equation for the Nusselt criteria (Nu = a RePr) for the type of flow in the pilot or production process; h is the height of the channel in the pilot or production process; and H is the overall volumetric heat transfer coefficient in the lab scale process.