'novel process for the synthesis of (2a,5b,7b,10b,13a)-4-acetoxy-13-({(2r,3s)-3(tertbutoxycarbonyl)amino-2-hydroxy-3-phenyl propanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate'

摘要

The present invention is related to a novel process of synthesis of (2α,5β,7β,10β,13α)-4-acetoxy-13-({(2R,3S)-3[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-l-hydroxy-7. 10-dimethoxy-9-oxo-5,20-epoxytax-ll-en-2-yl benzoate (Cabazitaxel) and its pharmaceutic ally acceptable salts.