An improved, industrially safe and economical process for the preparation of benzoxazole of formula i; a key intermediate for the preparation of mk-4305

摘要

Disclosed herein is an improved process for the preparation of Benzoxazole of formula I; a key intermediate for the preparation of MK-4305 via an advanced intermediate of formula II depicted herein above. The process comprises chip and commercially available starting materials using novel chemistry to synthesize benzoxazoles thereby reducing the cost of manufacture of key intermediate hence reducing the cost of advanced intermediate and MK-4305 thereby.