A METHOD OF MAKING A SUSTAINED RELEASE HOT MELT EXTRUDATES COMPOSITION

摘要

Sustained release hot melt extrudates using hot melt extrusion suitable for oral and ophthalmic drug delivery systems comprising at least one active pharmaceutical ingredient, at least one plasticizer and hydroxypropyl cellulose is discussed. The hot melt extrudates are used for oral and ocular drug delivery systems. These compositions are prepared by blending in an extruder or charging premixed to the extruder, active pharmaceutical ingredient, plasticizer and hydroxypropyl cellulose; heating the said blend; extruding the mixture as a long extrudate. The hot melt extrudates with other pharmaceutically acceptable excipients can be processed to granules, pellets, grains, minitablets, tablets or filled in capsules for oral administration or directly instilled in the eye for ocular drug delivery system.