A sustained release formulation coating methotrexate and folate nanoparticles and a method for preparing the same

摘要

A sustained release formulation containing methotrexate comprising a non covalently crosslinked (with multivalent cation salt) aqueous solution with methotrexate molecules neutralized with one of an alkali, an alkali earth metal hydroxide, or an alkali carbonate; guest molecules; surfactants, dispersants, additives; optionally including one or more nanoparticles.