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Dolutegravir or a pharmaceutically acceptable salt or solvate thereof, including sodium dolutegravir
Dolutegravir or a pharmaceutically acceptable salt or solvate thereof, including sodium dolutegravir
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机译:Dolutegravir或其药学上可接受的盐或溶剂化物,包括dolutegravir钠
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摘要
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ; R 1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R 2 is optionally substituted aryl; R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
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