SUBSTITUTED HETEROCYCLE (2-CARBOXY OR -METHOXYCARBONYL)PHENYLCARBAMOYL-METHYL (OR TRIMETHYLEN)-PYRIDINIUM OR ISOQUINOLINIUM BROMIDES AS HYDROXYCARBOXYLIC ACID RECEPTOR (HCA2) FAMILY NOVEL CLASS OF LIGANDS

摘要

The invention relates to biochemistry and medicine, particularly to substituted heterocycle [(2-carboxy or -methoxycarbonyl)phenylcarbamoyl-methyl (or trimethylen)]-pyridinium or isoquinolinium bromides as hydroxycarboxylic acid receptor (HCA) family (including niacin group) ligands for use in medicine for lipid, cholesterol and sugar metabolism as well as atherosclerotic inflammation process normalization and treatment.