New well characterized, crystalline acetone solvate of dimethoxy docetaxel, useful as anticancer and antileukemia agent, obtained by crystallization of dimethoxy docetaxel from aqueous acetone

摘要

The acetone solvate (A) of 4-acetoxy-2alpha -benzoyloxy-5beta ,20-epoxy-1-hydroxy-7beta ,10beta -dimethoxy-9-oxo-tax-11-en-13alpha -yl (2R,3S)-3-tert. butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I) (i.e. dimethoxy docetaxel) (preferably containing 5-7 wt. % acetone) is new. An independent claim is included for the preparation of (A). ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given in the source material.