Modified release pharmaceutical compositions of desvenlafaxine

摘要

A modified release pharmaceutical composition comprising Desvenlafaxine Benzoate (O-desmethylvenlafaxine benzoate), one or more release modifying agent(s) and one or more pharmaceutically acceptable excipient(s), wherein Desvenlafaxine Benzoate is characterized by a powder X-ray diffraction pattern having peaks at about 5.4, 10.75, 16.6, 18.0, 19.2, 23.32 ± 0.2 degrees. Also disclosed are specific modified release pharmaceutical compositions wherein concentration and AUC of the modified release composition are independent of food effect.