Oral pharmaceutical dosage form comprising a tamper proof Agent and / or repellent opioid antagonist, polyalkylene oxide and an Anionic Polymer

摘要

Refers to a pharmaceutical dosage form for oral Administration which has a tensile strength up to 300 N, comprising: (i) a pharmacologically Active Ingredient such as oxycodone; (ii) an opioid antagonist such as Naltrexone, naloxone and nalmefene, among others; and / or Agen You repellent; (iii) a polyalkylene oxide has an average Molecular Weight of 200000 g / mol; and (iv) an Anionic Polymer comprising Anionic Functional groups such as carboxyl groups, sulfonyl sulfate groups, Groups and phosphoryl groups; it also contains a plasticizer and an Antioxidant