New 2H indazoles as the target country of EP2 receiver

摘要

It refers to formula compound (I),R1 is h, alqilo C1-C2 or c1-c2-xil tar; R2 is h or methyl; R4 is h, C1-C4 tar, C3-C4 or ch2-cyclo C3-C4; X and R4 together form 4-6 member isomers through cyclic carbon alliance; m is 1 or 2; n is 1 or 2; AR is a residue of 10-5. R3 is halide, CN, sF5, C1-C4 tar, etc. They are the preferred compounds: 2 - [1 - [4 - (cyano-2-fluorobenzoil) piperidin-4-il] methyl} - N - (2-methoxy) - 4-methyl-2h-indazol-5-carboxamida; N - (2-methoxy) - 4-methyl-2 - [1 - (4-morfolinobenzoil) piperidin-4-il] methyl} - 2h-indazol-5-carboxamida;There are others It also refers to a method for making these compounds.