Pyrazole carboxamide derivatives as modulators of Taar - for use in the treatment of numerous disorders, such as Depression, Diabetes and Parkinson's disease

摘要

Relating to compounds of formula (i), where R1 is alkyl, phenyl cycloalkyl C1 - C7, C6 C1 - C3 - C7, alkoxy, cyano, among others; R2 is Hydrogen or alkyl of C1 - C7; R3 is Hydrogen or alkyl, amino C1 - C7; Z is a Link, - CH2 - or - or - or a Salt of the acid adding pharmaceutically suitable Same.These compounds have Affinity for the receptors associated with Trace amines (Taar), especially the TAAR1 and are useful in the treatment of depression, Anxiety Disorders, bipolar disorder, Attention deficit hyperactivity disorder (ADHD), ReLAC Disorders Ionados with stress, psychotic disorders, Schizophrenia, disease nuerologicas,Parkinson's disease, among others