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New indaniloxi dihidrobenzofuranil acetic acids

机译:新的茚达尼洛西二苯并呋喃乙酸

摘要

The Invention relates to compounds of the General formula I, where the Group G1 AR (HET) is defined according to claim 1, which bind to the receptor GPR40 and modulate its activity.Such compounds are suitable for the treatment and Prevention of diseases which can be influenced by this receptor, such as Metabolic Diseases, including Type 2 diabetes.Preferred compounds are: acid (S) - 6 - [(R) - 5 - fluoro - 2 - 4 - pirid iloxi - indan - 1 - iloxi] - 2,3 dihydro - benzofuran - 3 - {il} - acetic acid (S) - 6 - [(R) - 4 - (4 - cyano - phenoxy) - 5 - fluoro - indan] - 1 - iloxi 2,3 dihydro - methane - il - 3} - acetic acid, among others
机译:本发明涉及通式I的化合物,其中G1 AR(HET)基团是根据权利要求1定义的,其与受体GPR40结合并调节其活性。这种化合物适用于治疗和预防可会受到该受体的影响,例如包括2型糖尿病在内的代谢性疾病。首选化合物为:酸(S)-6-[(R)-5-氟-2-4-吡罗伊洛西-茚满-1-伊洛西]- 2,3二氢-苯并呋喃-3-{il}-乙酸(S)-6-[(R)-4-(4--氰基-苯氧基)-5-氟-茚满]-1-伊洛西2,3 -甲烷-il-3}-乙酸等

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