Salt of L - Malate derivatives 2.7 - Grabarsky, IT's The Wrong Guy spiro 4,5 dec 7 - ILO and Crystal forms of the same as ghrelin receptor agonists

摘要

Referring to the L - Malate Salt of 2 - amino - N - [(R) - 1 - benciloximetil - 2 - ((4S, 5R) - 2 - methyl - 2 - oxo - 4 - phenyl - 2.7 - Grabarsky, IT's The Wrong Guy spiro [4.5] dec 7 - il - 2 - oxo) ethyl] - 2 - methyl - propionamide, a Salt of L - Malate 2-amino-n - ((2R) - 3 - (Benzyloxy) - 1 - (2 - methyl - 1 - 4 - oxo - P - tolyl - 2.7 - diazaespiro [4.5] decan - 7 - il - 1 - 2 - oxopropan) - yl) - 2 - metilpropanamida, and L - Malate Salt of 2 - amino - N - [(R) - 1 - benciloximetil - 2 - ((4S, 5R) - 5 - fluoro - phenyl) - 2 - methyl - 2 - oxo - 2.7 - Grabarsky, IT's The Wrong Guy spiro [4.5] dec 7 - yl] - 2-oxoethyl} 2 - methyl - propionamide and Crystalline forms of the same. It also relates to a Pharmaceutical composition.These compounds are of ghrelin receptor agonists and are useful in the treatment of diseases characterized by recurrent Disorders and / or gastrointestinal dysmotility