Hexahidro - difluoro - difluoro - and ciclopentaoxacinilos hexahidro - benzooxacinilos as BACE1 inhibitors

摘要

Refers to ciclopentaoxacinilos difluoro - and difluoroenzooxacinilos Derivatives of formula (i) wherein R1, R2, R3, R4, R5, and N are as described in the present.Preferred compounds are: [3 - ((4S, 4aR, 7aR) - 2 - amino - 5.5 - difluoro - 4 - methyl - - - 4,4a 5,6,7,7a, hexahidro cyclopenta [e] [1,3] oxazin - 4-yl) phenyl] - 4 - fluoro - amide acid - 2 - 5 - but iniloxi - pyrazine carboxylic Acid - 2 - [3 - ((4S, 4aR, 7aR) - 2 - amino - 5.5 - difluoro - 4 - methyl - - - 4,4a 5,6,7,7a, hexahidro cyclopenta [e] [1,3] oxazin IL - 4 - 4 - fluoro) - phenyl] - 5 - (fluoromethyl acid amide pyrazine - 2 - carboxylic acid; among others.It also relates to pharmaceutical compositions. These compounds are BACE1 Inhibitory activity to be useful in the treatment of Alzheimer's disease