An expedient synthesis of alpha,alpha-difluoro-beta-hydroxy ketones via decarboxylative aldol reaction of alpha,alpha-difluoro-beta-keto acids with aldehydes

摘要

A novel decarboxylative aldol reaction of alpha,alpha-difluoro-beta-keto acids with aldehydes in the absence of any base and metal catalysts has been developed. This reaction provides a highly convenient and efficient method for the synthesis of structurally diverse ot,alpha,alpha-difluoro-beta-hydroxy ketones in good to excellent yields. (C) 2017 Elsevier Ltd. All rights reserved.