3-(31,51-DITERTBUTYL-41-HYDROXYPHENYL)-6,7-DIHYDRO-5H-PYROLYL1,2-AIMIDAZOLE HYDROCHLORIDE WITH ANTICANCER PROPERTIES

摘要

3-(31,51-ditertbutyl-41-hydroxyphenyl)-6,7-dihydro-5H-pyrolyl[1,2-a]imidazole hydrochloride with anticancer properties. This invention relates to organic and pharmaceutical chemistry and medicine, in particular pharmacologically active substances. This compound exhibits antitumor activity and can be used in the melanoma, renal cancer and breast cancer treatment. Investigation of antitumor activity is carried out in vitro on 60 cancer cell lines (leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast cancer). The claimed compound at a concentration of 10-5 mol/l exhibits the ability to inhibit the growth of cancer cells, covering virtually the entire spectrum of human cancers. It is shown that compound is the most effective towards to melanoma cells SK-MeL-5 (-88,80%), kidney cancer cells RXF-393 (-53,31%) and breast cancer MDA-MB-468 (-21,31 %).