Antibody to calcitonin Gene related Peptide (CGRP), Pharmaceutical composition containing same and use of said Antibody for preparing Medicine useful for treating Pain of osteoarthritis or migraines and fragment Antigen binding of the antibody

摘要

Antibody to calcitonin Gene related Peptide (CGRP) designed by Human Genetic Engineering, which comprises a variable region of light chain (lcvr) and a variable region of heavy chain (hcvr), where the lcvr comprises amino acid sequences lcdr1, lcdr2, lcdr3 and hcvr co Mprende amino acid sequences hcdr1, hcdr2, hcdr3, where lcdr1 is SEQ ID no 10,Lcdr2 is SEQ ID no 11, lcdr3 is SEQ ID no 5, hcdr1 is SEQ ID no 12 hcdr2 is SEQ ID no 37 hcdr3 is SEQ ID no 38, in which the Antibody binds to Human human CGRP, CGRP. Pharmaceutical composition containing same. Use of this Antibody for preparing a Medicament used for treating Pain of osteoarthritis or migraines. Fragment of Antigen binding of the Antibody.