Methods for treating Pain associated with Osteoarthritis in a joint with a topical formulation of a compound of espirooxindol

摘要

Methods for treating Pain associated with Osteoarthritis in a joint of a Mammal a Pharmaceutical composition comprising a compound of Spiro oxindole - with the following formula: Methods provide an excellent penetration of the compound of Spiro oxindole in the memb... Frog of the affected Joint synovial,It is useful to effectively reduce the intensity of Pain and / or to relieve Pain, to a Systemic exposure is minimal or negligible.