Not All Topical Corticosteroids are Created Equal! Optimizing Therapeutic Outcomes Through Better Understanding of Vehicle Formulations, Compound Selection, and Methods of Application

摘要

Since the first successful topical glucocorticosteroid, compound F, was applied to human skin to treat eczematous dermatitis approximately 60 years ago, several advances have been made in the development of topical corticosteroid (TC) compounds and vehicle formulations. (1-3)The ability to apply a TC and improve skin disease revolutionized dermatologic therapy and has proven to be one of the biggest advances in the history of dermatology. The potency of a TC and their vehicle formulation can vary among brand and generic TC compounds, which can sometimes confound the clinical situation as one brand or generic formulation of a givenTC may be well tolerated while another generic formulation induces skin irritation or allergenicity in a patient who previously encountered no difficulties. J Drugs Dermatol. 2012;11(suppl 12) s5-s8.