Truncated analogs of a glucose-dependent insulinotropic polypeptide

摘要

A compound of formula (I), ** Formula ** in which: A1 is deleted; A2 is Ala, 4Hppa, or is deleted; A3 is Glu, 4Hyp, Pro, or is deleted; A4 is Gly, or is deleted; A5 is Thr, or is deleted; A6 is Phe, or is deleted; A7 is A5c or A6c; A8 is Ser or Chc-Ser; A9 is Asp; A10 is Tyr; A11 is Ser, A6c or Aib; A12 is Ile; A13 is Ala or Aib; A14 is Met, A6c, or Nle; A15 is Asp; A16 is Lys; A17 is Ile; A18 is His; A19 is Gln; A20 is Gln; A21 is Asp; A22 is Phe; A23 is Val; A24 is Asn; A21 is Trp; A26 is Leu; A27 is Leu; A28 is Ala; A29 is Gln; A30 is Lys; A31 is Gly, Cys (Hsu), Cys (Psu), 2Nal, D-2Nal, Orn (NC (O) - (CH2) 4-CH3), Orn (NC (O) - (CH2) 8-CH3), Orn (NC (O) - (CH2) 12-CH3), or is deleted; A32 is Lys, Cys (Psu), or is deleted; A33 is Lys, Cys (Psu), or is deleted; A34 is Asn, Cys (Psu), Orn (N-C (O) - (CH2) 8-CH3), or is deleted; A35 is Asp, Cys (Psu), or is deleted; A36 is Trp, Cys (Psu), or is deleted; A37 is Lys, Cys (Psu), or is deleted; A38 is His, Cys (Psu), or is deleted; A39 is Asn, Cys (Psu), or is deleted; A40 is Ile, Cys (Psu), or is deleted; A41 is Thr, or is deleted; A42 is Gln, or is deleted; A43 is Gln, or is deleted; R1 is OH or NH2; each of R2 and R3 is independently selected from the group consisting of H or acyl (C1-C30); with the proviso that when R2 is acyl (C1-C30), then R3 is H; and with the proviso that when A2 is 4Hppa, then R2 and R3 are deleted; and with the proviso that at least one of A2, A3, A4, A5, A6, A8, A9, A11, A13, A14, A31, A32, A33, A34, A35, A36, A37, A38, A39 and A40 do not it is the amino acid residue of the corresponding position of the native GIP; or its pharmaceutically acceptable salt.