Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof

摘要

A genetically modified vesicular stomatitis virus (VSV) comprising two mutations that are a truncated G gene mutation in the cytoplasmic domain and a shuffled mutation of the N gene, so that the N gene is displaced from its wild position proximal to the 3 'promoter at a more distal position in the order of the VSV genes, in which the two mutations synergistically attenuate the pathogenicity of the VSV, in which the pathogenicity is further defined as neurovirulence.