Use of a metal colloidal solution to test the integrity of a virus removal membrane, procedure for the production of said solution and procedure to test the integrity of said membrane

摘要

Use of a colloidal solution of metal particles or particles of a metal compound, wherein said colloidal solution comprises at least (1) metal particles or particles of a metal compound having an average particle diameter of 1 to 100 nm, (2) a water soluble high molecular weight dispersant containing a group N, (3) water and / or a water soluble organic solvent, and (4) a surfactant and / or a chelating agent and having said colloidal solution following properties (a) and (b): (a) show a change in the maximum absorption wavelength in the range of -2.0 nm to +2.0 nm before and after being stored at room temperature for 180 days at a constant pH in a range of pH 4 to pH 11, and (b) show a change in the maximum absorption wavelength in the range of -1.3 nm to +2.0 nm before and after being stored at 50 ° C for one year at pH 5, to test the integrity of a membrane virus removal ana.