Substituted 3-phenyl-1- (phenylthienyl) propan-1-one and 3-phenyl-1- (phenylfuranyl) propan-1-one derivatives, preparation and use

摘要

Compounds derived from 3-phenyl-1- (phenylthienyl) propan-1-one and from substituted 3-phenyl-1- (phenylfuranyl) propan-1-one of general formula (I): ** Formula ** in which: X1 represents a halogen, a group R1, -SR1 or -OR1; X2 represents a sulfur or oxygen atom; X3 represents a halogen or an R3 group; X4 represents a halogen or an R4 group; X5 represents a -OR5 group; X6 represents a halogen or an R6 group; X7 represents a halogen or an R7 group; X8 represents a hydrogen atom; R1 representing a hydrogen or an alkyl group having 1 to 4 carbon atoms, said alkyl group being optionally halogenated; R3, R4, R6 and R7, identical or different, chosen from a hydrogen or an alkyl group having 1 to 4 carbon atoms; R5 representing an alkyl radical formed by a linear and saturated carbon chain, having 1 to 4 carbon atoms, said carbon chain being: - attached, at its opposite end to the phenyl group (III), to a -COOR12 substituent, representing R12 a hydrogen or an alkyl group having 1 to 4 carbon atoms; - unbranched or branched with at least one alkyl group having 1 to 4 carbon atoms; A represents: (i) a carbonyl group (CO), or (ii) a -CR9R10 group, R9 representing a hydrogen atom and R10 representing a -OR11 group, R11 being chosen from a hydrogen atom or an alkyl group (linear or branched) having 1 to 7 carbon atoms, said alkyl group being unsubstituted or substituted with a cycloalkyl group, mainly cyclohexyl, an aryl group, mainly phenyl or a heteroaryl group, mainly pyridinyl; B represents a saturated, unsubstituted alkyl group having two carbon atoms (CH2-CH2); their stereoisomers (diastereoisomers, enantiomers), pure or in mixture, racemic mixtures, geometric isomers, tautomers, salts, hydrates, solvates, solid forms as well as their mixtures