Method of assessing risk of progression of disease patients with rheumatoid arthritis

摘要

An in vitro method to aid in the assessment of risk of disease progression for a patient with rheumatoid arthritis (RA), the method comprising the steps of: a) measuring in a fluid sample the concentration of both the C reactive protein (CRP ) such as interleukin-6, and optionally one or more other markers, b) mathematically combining measured in step a) and c values) correlating the combined value determined in step b) with the risk of disease progression in said method of mathematical combination of the values ​​in step (b) is selected from AD (ie, linear discriminant analysis, quadratic, regularized), methods core (i.e. SVM), nonparametric methods (i.e. nearest neighbor classifiers k), CMP (partial least squares), tree-based methods (i.e. logic regression, CART, random forest methods, methods of "boosting") or general linear models hoisted (ie, logistic regression).