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Slow-discharge poly (lactide / glycolide) and methods for producing polymers
Slow-discharge poly (lactide / glycolide) and methods for producing polymers
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机译:慢排放聚(丙交酯/乙交酯)及其制备方法
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摘要
A method of preparing a biocompatible, biodegradable, non-hydrolyzed PLG slow-release copolymer material for a controlled release formulation having a weight average molecular weight of 10 kilodaltons to 50 kilodaltons and a polydispersion index of 1.4-2 , 0 and from which a deleted copolymer fraction characterized by a weight average molecular weight of 4 kDa to 10 kDa and a polydispersion index of 1.4 to 2.5 has been separated, the method comprising separating a deleted copolymer fraction characterized by a weight average molecular weight of 4 kDa to 10 kDa and a polydispersion index of 1.4 to 2.5 from starting PLG copolymer material, dissolve the starting PLG copolymer material in a solvent to provide a solution , the PLG slow discharge copolymer material then precipitating by contacting the solution with a non-solvent and collecting PL slow discharge copolymer material G precipitate, the method not comprising any step of hydrolysis of a PLG copolymer of greater molecular weight.
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