ADOPTIVE IMMUNOTHERAPY WITH ENHANCED T LYMPHOCYTE SURVIVAL

摘要

The invention provides for compositions, e.g., pharmaceutical compositions,comprising a T lymphocyte, or a population thereof, expressing at least onerecombinant polynucleotide encoding a cytokine that enhances T lymphocytesurvival during the contraction phase of an immune response. The inventionfurther provides an isolated T lymphocyte, or population thereof, expressingat least one recombinant polynucleotide encoding the cytokine, wherein thepolynucleotide comprises a non-native coding sequence encoding the cytokine.Also provided is the use of such compositions and T lymphocytes, orpopulations thereof, for the treatment or prevention of a medical conditione.g., cancer. A method of preparing the a T lymphocyte with enhanced T cellsurvival is further provided herein.