Adoptive Transfer of Variant-Specific Resistance to 'Trypanosoma rhodesiense' with 'B' Lymphocytes and Serum.

摘要

Mice develop augment resistance against infection by Trypanosoma rhodesiense when previously inoculated with irradiated organisms. This resistance demonstrates immunologic specificity as no augmentation of resistance is observed when animals are challenged with non-homologus or variant strains. Although the mechanisms of this resistance is not clear, it can be adoptively transferred to syngeneic recipients with both B lymphocytes and serum. However, the immunologic status of the animal is not closely correlated with the ability of its cells or serum to adoptively transfer resistance. These findings indicate that resistance to T. rhodesiense is the result of a complex interaction involving a number of serologic components and subpopulations of cells. (Author)