METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA

摘要

The present invention provides a method of treating cancer by providing to asubject in need thereof an immunogenic composition comprising a nucleic acidconstruct encoding a polypeptide comprising CTL epitopes PSMA288-297 andPRAME425-433, or a cross-reactive analogue. In embodiments of the presentinvention there is provided methods and compositions for inducing, entraining,and/or amplifying the immune response to MHC class-I restricted epitopes ofcarcinoma antigens to generate an effective anti-cancer immune response.