ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS AND ANIONIC ORGANIC COMPOUNDS FOR USE AS DISPLACER COMPOUNDS IN ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS

摘要

A displacement chromatography process, including: loading onto a stationaryphase comprising an anion-exchange material a mixture comprising one or morecomponent to be separated; displacing at least one of the one or morecomponent from the stationary phase by applying to the stationary phase amixture comprising an polyaromatic polyanionic displacer compound having ageneral formula Cen (Ar)w, in which Cen is a central bond or group, Ar is anaromatic nucleus, w = 2 to the maximum number of sites one Cen, and Ar issubstituted with a plurality of An-, in which each An- is independentlydefined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar isfurther substituted with a plurality of G, in which G is defined asindependently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy Inaddition, a group of polyaromatic polyanionic displacer compounds useful inthe process is disclosed.