TUMOR-TARGETING MULTI-MODE IMAGING METHOD FOR LIVING BODY BASED ON GOLD NANOCLUSTERS

摘要

A tumor-targeting multi-mode imaging and analyzing method for living body based on gold nanoclusters, comprises: through an in-vitro cell experiment including various types of tumor cells and normal cells, incubating the relevant cells, chloroauric acid and the salt solution thereof with certain concentration under physiological conditions and generating gold nanoclusters, and thereby realizing real-time non-invasive fluorescence imaging, Raman imaging and ultrasonic imaging for tumor cells with high resolution. Based on this, a local subcutaneous injection method is adopted, and real-time in-situ living body tumor-targeting fluorescence imaging, Raman imaging and ultrasonic imaging are realized on tumor-transplantation nude mouse models. With the functional nano-scale probes, multiple functions of tumor targeting, fluorescence imaging, Raman imaging and ultrasonic imaging are combined, therefore synchronous monitoring of multiple modes can be achieved. Meanwhile, with the in-situ living body imaging method based on gold nanoclusters, accurate positioning and tumor-targeting imaging and analysis can be realized.