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METHODS FOR DIAGNOSING AND TREATING BICUSPID AORTIC VALVE AND/OR AORTOPATHIES

机译:诊断和治疗双主动脉瓣和/或主动脉病变的方法

摘要

Provided herein are methods for identifying and treating BAV disease and/or aortopathy in a subject, and methods of improving outcome in a subject. The subject may be asymptomatic of BAV disease and/or aortopathy, experiencing symptoms of BAV disease and/or aortopathy, have BAV disease and/or aortopathy, or be a blood relative of an individual having BAV disease and/or aortopathy. Levels of sRAGE in the subject's biological sample are determined, compared to a control biological sample, and used as an indicator for the presence and severity of BAV disease and/or aortopathies, a tool to screen family members, and an indicator of the proper surgical or treatment regimens.
机译:本文提供了用于鉴定和治疗受试者中的BAV疾病和/或主动脉病变的方法,以及改善受试者的预后的方法。该受试者可以是无症状的BAV疾病和/或主动脉病,经历过BAV疾病和/或主动脉病的症状,患有BAV疾病和/或主动脉病,或者是患有BAV疾病和/或主动脉病的个体的血亲。确定受试者生物样品中sRAGE的水平,并与对照生物样品进行比较,并将其用作BAV疾病和/或主动脉病变的存在和严重程度的指标,筛查家庭成员的工具以及适当手术的指标或治疗方案。

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