METHODS FOR QUANTITATIVE DETERMINATION OF PROTEIN-NUCLEIC ACID INTERACTIONS IN COMPLEX MIXTURES

摘要

In various embodiments, the present invention relates generally to analysis of complex mixtures and, more specifically, to detection and quantitative determination of multiple proteins, protein modifications, mechanisms of drug action and protein-nucleic acid interactions in those complex mixtures. Identification vehicles each consisting essentially of (a) a binding portion specific to a unique protein in the mixture and (b) an encoding nucleic acid portion are employed. The associated nucleic acids are sequenced to quantify the proteins corresponding thereto.