CATIONIC GRAFT-COPOLYMER FOR NON-VIRAL GENE DELIVERY VECTOR

摘要

A cationic graft-copolymer for a non-viral gene delivery vector comprising a unit derived from a cationic derivative of a water-soluble linear polymers having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1) [C6H7O2 (OH)3-a (OX)a ]x H2O (1) and the cationic derivative of polyvinylalcohol of the following formula (2) or the cationic derivative of the partial hydrolyzed polyvinylalcohol of the following formula (3) [CH2 CH(OH)1-b (OX)b ]n (2) [CH2CH(OH)1-b-c (OX)b (OAc)c ]n (3) and a unit derived from a polymerizable olefin compound of the following formula (4) R4 R6 | | - C - C - (4) | | R5 R7(a, x, b, n, c, Ac, X, R4, R5, R6, and R7 are defined in claim 1-6); a process for preparing the same and a transfection reagent made therefrom..