METHODS AND KIT FOR ANALYSES OF METHYLATION IN COLORECTAL CELLULAR PROLIFERATIVE DISORDERS

摘要

The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders based on underexpression or methylation of a least one gene selected from RASSF2, TFAP2E, SNDl, PCDHGC3, EDNRB, STOM, GLI3, RXFP3, LimKl, GPR73L1, PCDHlO, DOCKIO and MRPS21, and optionally Septin-9. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said class of disorders, thereby enabling the improved diagnosis and treatment of patients.