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Method of modulation of expression of epidermal growth factor receptor (EGFR) involving miRNA
Method of modulation of expression of epidermal growth factor receptor (EGFR) involving miRNA
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机译:调节涉及miRNA的表皮生长因子受体(EGFR)表达的方法
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摘要
The present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) and its downstream signalling effectors. In particular, the present invention relates to a method for modulating the expression of epidermal growth factor receptor (EGFR) or like molecule in a cell comprising contacting said cell with an agent capable of directly or indirectly interacting with the 3'-untranslated region (UTR) of the mRNA of said EGFR or like molecule, wherein the UTR is encoded by a sequence which comprises a sequence having at least about 70% identity with at least one sequence selected from the group consisting of the sequences set forth in SEQ ID NOs: 1-36.
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机译:本发明涉及一种调节表皮生长因子受体(EGFR)的表达的方法及其下游信号传导效应子。特别地,本发明涉及用于调节细胞中表皮生长因子受体(EGFR)或类似分子的表达的方法,该方法包括使所述细胞与能够直接或间接与3'非翻译区(UTR)相互作用的试剂接触。 )所述EGFR或类似分子的mRNA,其中UTR由包含与至少一个选自SEQ ID NOs所示序列的序列具有至少约70%同一性的序列的序列编码: 1-36。
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