METHODS FOR PREDICTING TOXICITY IN RESPONSE TO TREATMENT WITH A DRUG BY ASSESSING ACTIVATION OF THE STEROL REGULATORY BINDING PROTEIN (SREBP) PATHWAY

摘要

The present disclosure provides methods for predicting whether a drug (e.g., a tyrosine kinase inhibitor) is likely to be toxic to a cell or biological sample by assessing whether pathways (e.g., the SREBP pathway) that lead to the production of fatty acids and/or cholesterol are activated in the cell and/or biological sample upon treatment of the cell or biological sample with the drug. Such methods may be used to select cells or biological samples predicted to be responsive (i.e., sensitive) to treatment with a drug for treatment with the drug.