MIR-133α AS A MARKER AND THERAPEUTIC TARGET FOR COLITIS AND INFLAMMATORY BOWEL DISEASE

摘要

The invention provides a method for detection and monitoring of inflammatory bowel disease (IBD) in a subject that comprises assaying a specimen from the subject for miR-133α, AFTPH, and, optionally NTSR1. An elevated amount of miR-133α and/or NTSR1, and/or a decreased amount of AFTPH, present in the specimen compared to control sample is indicative of inflammation. The invention further provides a method of treating inflammatory disease, such as IBD or colon cancer, in a subject by administering an inhibitor of miR-133α.