ANALYZING IMMUNE SIGNALING NETWORKS FOR IDENTIFICATION OF THERAPEUTIC TARGETS IN COMPLEX CHRONIC MEDICAL DISORDERS, IDENTIFICATION OF A NATURAL KILLER CELL POPULATION AS A POTENTIAL THERAPEUTIC TARGET FOR GULF WAR ILLNESS amp; MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME, AND MODULATION OF NATURAL KILLER CELL FUNCTION BY STIMULATION WITH INTERLEUKIN 15

摘要

A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3-/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin- 15 (IL-15).