首页> 美国卫生研究院文献>Biological Research >Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients
【2h】

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients

机译:在自然杀伤细胞和B淋巴细胞上的瞬时受体潜在褪黑素3离子通道的新型鉴定和表征:对慢性疲劳综合征/肌病性脑脊髓炎患者细胞信号的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

BackgroundTransient receptor potential melastatin 3 (TRPM3) cation channels are ubiquitously expressed by multiple cells and have an important regulatory role in calcium-dependent cell signalling to help maintain cellular homeostasis. TRPM3 protein expression has yet to be determined on Natural Killer (NK) cells and B lymphocytes. Multiple single nucleotide polymorphisms have been reported in TRPM3 genes from isolated peripheral blood mononuclear cells, NK and B cells in Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) patients and have been proposed to correlate with illness presentation. The object of the study was to assess TRPM3 surface expression on NK and B lymphocytes from healthy controls, followed by a comparative investigation examining TRPM3 surface expression, and cytoplasmic and mitochondrial calcium influx in CD19+ B cells, CD56bright and CD56dim cell populations from CFS/ME patients.
机译:背景瞬态受体潜在的褪黑素3(TRPM3)阳离子通道在多个细胞中普遍表达,并且在钙依赖性细胞信号传导中具有重要的调节作用,以帮助维持细胞稳态。 TRPM3蛋白表达尚未确定在自然杀伤(NK)细胞和B淋巴细胞上。慢性疲劳综合征/肌性脑脊髓炎(CFS / ME)患者的外周血单核细胞,NK和B细胞中分离出的TRPM3基因中已报告了多个单核苷酸多态性,并已提出与疾病表现相关。该研究的目的是评估健康对照组的NK和B淋巴细胞上TRPM3的表面表达,然后进行对比研究,检查CD19 + B细胞,CD56中TRPM3的表面表达以及胞质和线粒体钙内流。 CFS / ME患者的 bright 和CD56 dim 细胞群体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号