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METHOD AND DEVICE FOR HIGH RESOLUTION FULL FIELD INTERFERENCE MICROSCOPY

机译:高分辨率全场干涉显微镜的方法和装置

摘要

The invention relates to an incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample (106). The device comprises an interference device (100) between a reference wave (401), produced by reflection of an incident wave by a reflective surface (105) of a reference arm of the interference device, and an object wave (402) produced by backscattering of the incident wave by a slice of the sample, an acquisition device (108) for at least a first interference signal and at least a second interference signal resulting from the interference of the reference and object waves, the at least two interference signals having a phase difference, an processing unit (403) for calculating an image of the slice of the sample, based on said interference signals. The interference device also comprises an optical element (404) for modifying the phase of the wavefront, and the microscopy device comprises a control unit (405) for the optical element, linked to the processing unit (403), the optical phase modification element being controlled by optimizing a statistical parameter of at least a part of the image calculated by the processing unit.
机译:本发明涉及一种用于对体积散射样品(106)进行成像的非相干光全场干涉显微镜设备。该装置包括干涉装置(100),该干涉装置(100)在通过入射波被干涉装置的参考臂的反射表面(105)反射而产生的参考波(401)和通过反向散射而产生的物波(402)之间。通过样本切片的入射波,获取装置(108),用于至少由参考波和物波的干扰产生的第一干扰信号和至少第二干扰信号,所述至少两个干扰信号具有相位差,处理单元(403),用于基于所述干扰信号来计算样本的切片的图像。干涉装置还包括用于改变波前的相位的光学元件(404),显微镜装置包括用于光学元件的控制单元(405),该控制单元链接到处理单元(403),光学相位改变元件是通过优化处理单元计算的图像的至少一部分的统计参数来控制图像。

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