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METHOD FOR SUPPRESSING RECEPTOR TYROSINE KINASE-MEDIATED PROSURVIVAL SIGNALING IN CANCER CELLS
METHOD FOR SUPPRESSING RECEPTOR TYROSINE KINASE-MEDIATED PROSURVIVAL SIGNALING IN CANCER CELLS
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机译:抑制受体酪氨酸激酶介导的生存信号在癌细胞中的方法
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摘要
In order to provide a screening method for a compound capable of suppressing a mechanism of ROR1 by targeting ROR1 and to provide a drug comprising as an active ingredient a compound capable of suppressing the mechanism, it has been found out that suppressing a function of ROR1 makes it possible to suppress receptor tyrosine kinase-mediated pro-survival signaling in a cancer cell. Further, it has been found out that suppressing a function of ROR1 also effectively suppresses growth of cancer cell lines having acquired resistance to inhibitors of receptor tyrosine kinases such as EGFR and MET.
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