1,2-cyclohexandiamin platinum(II) bis-(4-methylbenzolsulfonate) and its hydrates

摘要

1,2-Cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) dihydrate (A), is new. Independent claims are also included for: (1) preparing (A); (2) using 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) and its hydrates as a reference standard for (SP-4-2)-diaqua[(1R, 2R)-cyclohexane-1,2-diamine-kappa-N,kappa-N'] platinum, comprising (i) providing a solution of oxaliplatinum, (ii) providing a solution of 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) or its hydrate as the reference standard, (iii) carrying out chromatographic absorption of oxaliplatinum solution from step (i), (iv) carrying out chromatographic absorption of the reference standard solution from the step (ii), and, (v) comparing chromatographic absorption from the steps (iii) and (iv) to determine the amount of (SP-4-2)-diaqua [(1R, 2R)-cyclohexane-1,2-diamine-kappa-N, kappa-N?]platinum; and (3) using 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) and its hydrates for producing polymer-bound cyclohexane-platinum(II) complexes, comprising (ia) providing 1,2-cyclohexane diamine platinum(II) bis(4-methylbenzenesulfonate) or its hydrate, (ib) providing the polymer comprising at least one groups, which are introduced into a bond with platinum, (ic) reacting 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) or its hydrate with the polymer in a solvent.