TAILORED COMBINATORIAL EPIGENETIC THERAPIES FOR P53 GAIN-OF-FUNCTION TUMORS

摘要

The present invention provides compositions and methods for treating and preventing cancer. The invention comprises an inhibitor of epigenetic regulators, including MLLl, MLL2, MOZ, menin, WDR5, or a combination thereof. In one embodiment, the invention provides a personalized method of treating a cancer as dependent upon its epigenetic signature.