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ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF
ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF
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机译:金属蛋白酶4(TIMP-4)抗体的抗组织抑制剂及其使用方法
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摘要
Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment, the disease or disorder is cancer, particularly breast, brain, ovarian, and/or esophageal cancer, or osteoarthritis, or cardiovascular disease. In a particular embodiment, the cancer over-expresses TIMP-4 and/or has aberrant TIMP-4 activity/function, e.g., overactivity. The methods comprise administering a therapeutically effective amount of the anti-TIMP-4 antibodies of the invention to a subject, e.g.,' as part of a pharmaceutical preparation.
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