Active implantable medical device for nerve therapy with stochastic stimulation of the vagus nerve

摘要

the device includes a generator producing pulse bursts (si) n (i) stimulation vns generated in succession during periods of activity (a) separated by intervening periods of inactivity (toff) in which no stimulus is delivered e.stochastic modulation means control the issuance of each burst of pulses of each burst is vns by selective inhibition, or not, of the generation of each pulse as a function of the result of the vns a random draw.we vary the number of pulses during each round of vns and the energy of stimulation vns this round and the interval between successive pulses, thus the emergence of a loop of physiological compensation.