首页>
外国专利>
METHODS OF TREATING CANCER PATIENTS RESPONDING TO EZH2 INHIBITOR GSK126
METHODS OF TREATING CANCER PATIENTS RESPONDING TO EZH2 INHIBITOR GSK126
展开▼
机译:治疗针对EZH2抑制剂GSK126的癌症患者的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed herein are methods of treating cancer in a human, where the methods include determining at least one of the following in one or more samples from the human: the presence or absence of an alanine to valine mutation at residue 687 (A687V) in EZH2 in a sample from the human; or the presence or absence of an increased level of H3K27me2 in a sample from the human as compared to a control; and administering to the human an effective amount of the EZH2 inhibitor GSK126 or a pharmaceutically acceptable salt thereof if the A687V mutation is present, or an increased level of H3K27me2 is not present, or both, in the one or more samples, which is indicative of an increased likelihood of increased response rate and/or prolonged progression free survival. Also disclosed are uses of the compound of the EZH2 inhibitors, uses of pharmaceutical compositions comprising the EZH2 inhibitors, and kits containing means for determining the mutations or methylation levels for use with the methods described.
展开▼