A method of Raman spectroscopic structure investigation of a sample that includes a dispersed chemical species, in particular a protein, in a liquid phase and an apparatus for performing said method are described. The method comprises: providing the sample; providing marker particles in the sample; exciting the sample with a light source; receiving Raman-scattered light from the dispersed chemical species in the sample; detecting, from the received Raman-scattered light, Raman scattering from the dispersed chemical species in the sample; detecting movement of the marker particles in the sample; and extracting at least one characteristic of the dispersed chemical species in the sample from both the step of detecting Raman scattering and the step of detecting movement of the particles.
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